Whether you’re contemplating CBD oil for a medical reason or just because you’re interested, keep in mind that it may take up to 4 days for your body to fully eliminate it. It’s also possible that they’ll persist much longer if you’re using a prescription that produces drug-drug interactions with CBD.
It is hoped that this information will assist you in learning more about how long CBD (cannabidiol) stays in the body and the potential consequences of this on medicines.
Let’s start with the “4-to-5-day timeframe” that has been mentioned. The simple answer is that it is safe to consume CBD-rich products for four or five days in a row if you are not taking any other medicines that may interfere with their effects on your body. If you are taking any competing medications and/or supplements that may interact with cannabidiol, they could be the cause of any awkward feedback or other GI issues you might experience.
What happens to your body when you consume CBD?
Before I go into more depth regarding how long it takes for CBD to exit your system, let’s look at what occurs when you consume the substance. As a result of ingesting cannabidiol, it will enter your bloodstream and be transported by your liver to the liver cells (hepatocytes), where it will be broken down and released into your systemic circulation (where it gets distributed to the rest of your body).
Absorption and breakdown
This marks the beginning of the process of absorbing CBD and breaking it down. Everything else is regulated in part by a complex cascade of metabolic processes including enzymatic reactions, which are catalyzed by enzymes that act on lipids, carbohydrates, proteins, and other substances. Enzymes are also involved in the metabolism of vitamin D and other chemicals.
The liver phase
The liver is responsible for breaking down all the fatty acids in your circulation and dumping them into your bile cells, which are then expelled via the liver. This assists in the removal of harmful fats as well as excessive water.
Once the triglycerides (held fats) stored in fat cells are converted by the liver into ketones, the ketones are utilized by the brain and other organs, which is especially important during times of famine. In times of fasting or low blood sugar, the ketones produced by this process serve as an alternative fuel source for the brain, allowing it to operate at peak performance.
The utilization of energy in this manner, however, is not particularly efficient; it requires a huge amount of energy production simply to break down lipids and keep hunger at bay throughout the fasting period.
When you stop to think about it, this is a fantastic method to store energy (in the form of fats) and take advantage of moments when you need it. This mechanism also contributes to the understanding of why obesity is associated with the metabolic syndrome (when various systems in your body are not optimized).
Next, the fat in your liver cells will be metabolized by your body into fatty acids, which will then be utilized as a fuel source for other tissues. If the body is unable to utilize fat as a fuel source because of a lack of fatty acids being produced by the liver because of fasting, it may take up to two weeks for the body to produce new cholesterol from the ground up.
The question is, how does this mechanism contribute to the breakdown of CBD?
The liver is very essential in the metabolism of cannabis and other cannabinoids. CBD, like other cannabinoids, is processed by enzymes known as cytochrome P450s, which are found in the liver. To metabolize cannabidiol, the first enzyme to do so is CYP3A4, which is located mostly in the liver cells of your body.
As previously said, cannabidiolwill enter your circulation and be carried to your liver, where it will be broken down into 11-hydroxy-CBD and 7-hydroxy-CBD, as well as other constituents. Both metabolites are cannabinoids in their own right. They do not have the intoxicating effects of THC, but they may bind weakly to both CB1 and CB2 receptors in the endocannabinoid system, which is like THC (ECS).
Depending for how long you’ve been using CBD, the following factors may contribute to an increase in its levels in your blood stream:
- When you take cannabidiol on a regular basis, it will accumulate in your bloodstream due to the way it is processed by the liver.
- If you have higher than normal CYP3A4 enzyme activity.
- If you are taking any other medications or supplements that may interact with the enzymes involved in CBD metabolism.
What do the studies say:
In addition, the fact that CBD does not remain in the body for long periods of time may help to explain why some studies have produced conflicting results – for example, a study in which one group received 1200mg daily for 14 days found no effects, whereas another study in which another group received 600mg daily for 12 weeks found results.
The length of time cannabidiol stays in your system before and after you’ve taken it has already been discussed in detail on this blog post. When using a CBD product daily (or more than once or twice a week), the half-life is estimated to be between 3-5 days, with the majority of individuals reporting that the effects are gone by 4 days. If you take less than this (a dosage that should last about one week), the half-life will typically be between seven and ten days in most cases.
Consider the fact that various dosages generate varied outcomes when contemplating why some individuals enjoy advantages from greater doses while others have no impacts at all – maybe an interaction with their liver enzyme activity, as I described above might explain this.
As a result, if you consume CBD products that contain different levels of CBD (and therefore are not all equal in terms of absorption rate), you will notice a difference in how long it takes for your body to rid itself of the residual cannabinoids. Since it contains more raw material or active ingredients for the enzymes involved in metabolizing it, higher concentrations of hemp oil or products with higher CBD concentrations may have a longer half-life than lower concentrations of hemp oil or products with lower CBD concentrations.
Although it is very personal how long it takes for CBD to leave your bloodstream, in general, most individuals should be able to consume cannabidiol without any problems and get the advantages of doing so. I hope this post was helpful, keep posted on our blog for more interesting information and If you like the science behind CBD, keep reeding about it on CBD clinical trials!